NCI-COG Pediatric MATCH Trial Now Open

The NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice) trial was activated on July 24, 2017. NCI-COG Pediatric MATCH, the first pediatric precision medicine cancer treatment trial of this scale, is open at approximately 200 U.S.-based Children’s Oncology Group (COG) member cancer centers and community hospitals. The study was developed and will be led jointly by the NCI and COG.

The NCI-COG Pediatric MATCH trial:

  • Seeks to enroll children and adolescents from 12 months to 21 years of age who have solid tumors, including non-Hodgkin lymphomas, brain tumors, and histiocytoses, that no longer respond to standard treatment or have recurred after treatment.
  • Requires patients to have a tumor sample (formalin fixed paraffin embedded tissue) available for molecular characterization from the time the tumor recurred or progressed after treatment, which will undergo DNA or RNA sequencing to detect genetic abnormalities that could be targeted by one or more of the drugs being studied. If an identified abnormality matches a drug in one of the treatment arms that targets that abnormality, the patient can enroll in that arm if he or she meets the eligibility criteria.
  • Is opening with approximately six treatment arms and is expected to expand to eight or more as the trial progresses. The trial investigators project that 200-300 patients will be screened per year, for a total of 1,000 patients screened, and that cancer mutations for which study drugs are available will be found in about 10% of the tumors screened.
  • In contrast to the adult MATCH trial, Pediatric MATCH will include a germline analysis of peripheral blood from the patient to detect whether mutations identified in the tumor are inherited so that the treating physician can provide guidance to the patient’s family regarding the need for formal genetic testing, counseling and follow-up care even if the patient does not match to a treatment arm.

To learn more about this trial, patients/families should start by talking with their doctors or health care team.  To locate trial sites, visit Find a Children’s Oncology Group Location. For more information, visit or Or call the NCI’s Contact Center (formerly known as the Cancer Information Service) at 1-800-4-CANCER (1-800-422-6237) for assistance in English and Spanish, or visit and contact NCI's LiveHelp online service.    

To read press release about trial opening, click here.